Kenneth Weber

DC, PhD

Instructor, Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Division of Pain Medicine, Systems Neuroscience and Pain Lab

Email: kenweber@stanford.edu

Twitter: @DrKenWeber

ResearchGate: Kenneth Weber

KenWeber.jpg
 

Research interests and skills

My research seeks to develop markers of pain and physical function using machine-learning and advanced brain, spinal cord, and musculoskeletal magnetic resonance imaging. I aim to use these techniques to better understand the neuropathology of pain and neurological conditions and discover more effective treatments and preventative strategies.

 

Ongoing research

  • Deep-Learning Models for Automated Segmentation of Muscles (CARL project with Kenneth Weber and Hazel Jenkins)

 

Research publications

Berliner JC, O’Dell DR, Albin SR, Dungan D, Sevigny M, Elliott JM, Weber II KA, Abdie DR, Anderson JS, Rich AA, Seib CA, Sagan HGS, Smith AC. The influence of conventional T2 MRI indices in predicting who will walk outside one year after spinal cord injury, Journal of Spinal Cord Medicine, In Press.

Reed WR, Weber II KA, and Martins DF. Editorial: Mechanisms and models of musculoskeletal pain and nonpharmacological treatment. Front Integr Neurosci, 2022;16:998413.

Wesselink EO, Elliott JM, Coppieters B, Cronin M, Hancock M, Pool-Goudzwaard A, Weber KA. Convolutional neural networks for the automatic segmentation of lumbar paraspinal muscles in people with low back pain, Scientific Reports, 2022;12:13485.

Perraton Z, Lawrenson P, Mosler AB, Elliott JM, Weber II KA, Flack N, Cornwall J, Crawford RJ, Crossley K, Stewart C, Semciw AI. Towards defining muscular regions of interest from axial magnetic resonance imaging with anatomical cross-reference: A scoping review of lateral hip musculature. BMC Musculoskelet Disord, 2022;23:533.

Franettovich Smith MM, MD Mendis, Ho R, Wilkes MJ, Elliott JM, Weber II KA, Collins NJ. Improving the measurement of intrinsic foot muscle volumes from high-field (7T) magnetic resonance imaging. Journal of Biomechanics, 2022;140:111164.

Galassia T, Fernandesa PF, Salgado ASI, Cidral-Filhoa FJ, Piovezan AP, Lüdtke DD, Mack JM, Babinskis B, Weber KA, Reed WR, Bobinski, Martins DF. Preventive Supplementation of Omega-3 Reduces Pain and Pro-Inflammatory Cytokines in a Mouse Model of Complex Regional Pain Syndrome Type I, Front Integr Neurosci, 2022;16:840249.

Smith AC, O’Dell DR, Thornton WA, Dungan D, Robinson E, Ashesh T, Gisbert R, Weber II KA, Berliner JC, Albin SR. Spinal cord tissue bridges validation study: predictive relationships with sensory scores following cervical spinal cord injury, Top Spinal Cord Inj Rehabil, 2022;28(2):111-115.

Bodkin SG, Smith AC, Bergman B, Hou D, Weber KA, Harris-Love M. Utilization of Mid-Thigh Magnetic Resonance Imaging to Predict Lean Body Mass and Knee Extensor Strength in Obese Adults, Frontiers in Rehabilitation Sciences, 2022;3:808538.

de Zoete, RM, Stanwell P, Weber II KA, Snodgrass S. Differences in Structural Brain Characteristics between Individuals with Chronic Nonspecific Neck Pain and Asymptomatic Controls: A Case-Control Study, Journal of Pain Research, 2022;15:521-531.

Smith AC, Angeli CA, Ugiliweneza B, Weber II KA, Negahdar M, Mesbah S, Boakye M, Harkema SJ, Rejc E. Spinal Cord Imaging Markers and Recovery of Standing with Epidural Stimulation in Individuals with Clinically Motor Complete Spinal Cord Injury, Experimental Brain Research, 2022;24(1):279-288.

Smith AC, O’Dell DR, Albin SR, Berliner JC, Dungan D, Robinson E, Elliott JM, Carballido-Gamio J, Stevens-Lapsley J, Weber II KA. Lateral corticospinal tract and dorsal column damage: predictive relationships with motor and sensory scores at discharge from acute rehabilitation after spinal cord injury, Archives of Physical Medicine and Rehabilitation, 2022;103(1):62-68.

Gilam G, Cramer EM, Weber II KA, Ziadni M, Kao MC, Mackey S. Classifying chronic pain using multidimensional pain-agnostic symptom assessments and clustering analysis, Science Advances, 2021;7(37):eabj0320.

Cohen-Adad J, Alonso-Ortiz E, Abramovic M, Arneitz C, … Weber II KA, Weiskopf N, Wise RG, Wyss PO, Xu J. Open-access MRI data of the spinal cord and reproducibility across participants, sites, and manufacturers. Scientific Data, 2021;8:219.

Cohen-Adad J, Alonso-Ortiz E, Abramovic M, Arneitz C, … Weber II KA, Weiskopf N, Wise RG, Wyss PO, Xu J. Generic acquisition protocol for quantitative MRI of the spinal cord. Nature Protocols, 2021.

Weber II KA, Abbott R, Bojilov V, Smith AC, Wasielewski M, Hastie TJ, Parrish TB, Mackey S, Elliott JM. Multi-Muscle Deep Learning Segmentation to Automate the Quantification of Muscle Fat Infiltration in Cervical Spine Conditions. Scientific Reports, 2021;11:16567.

Martucci KT, Weber II KA, Mackey S. Spinal Cord Resting State Activity in Individuals with Fibromyalgia Who Take Opioids. Frontiers in Neurology, 2021;12:1251.

Smith AC, Albin SR, O’Dell DR, Berliner JC, Dungan D, Sevigny M, Draganich C, Elliott JM, Weber II KA. Axial MRI biomarkers of spinal cord damage predict future walking and motor function. Spinal Cord, 2021;59(6):693-699.

Paliwal M, Weber KA II, Smith AC, Elliott JM, Muhammad F, Dahdaleh NS, Bodurka J, Dhaher Y, Parrish TB, Mackey S, Smith ZA. Fatty infiltration in cervical flexors and extensors in patients with degenerative cervical myelopathy using a multi-muscle segmentation model. PLoS ONE, 2021;16(6):e0253863.

Nim GC, Weber KA, Kawchuk G, O’Neill S. Spinal Manipulation and Modulation of Pain Sensitivity in Persistent Low Back Pain. Chiropr Man Therap, 2021;29:10.

Franettovich Smith MM, Elliott JM, Al-Najjar A, Weber II KA, Hoggarth MA, Vicenzino B, Hodges PW, Collins NJ. New insights into intrinsic foot muscle morphology and composition using ultra-high-field (7-Tesla) magnetic resonance imaging. BMC Musculoskelet Disord, 2021;22(1):97.

Côté P, Hartvigsen J, Axén I, Leboeuf-Yde C, … Weber K, Young KJ, and Yu H. The Global Summit on the Efficacy and Effectiveness of Spinal Manipulative Therapy for the Prevention and Treatment of Non-musculoskeletal Disorders A Systematic Review of the Literature. Chiropr Man Therap, 2021;29:8.

Hoggarth MA, Elliott JM, Smith ZA, Paliwal M, Kwasny MJ, Wasielewski M, Weber II KA, Parrish TB. Macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision. Scientific Reports, 2020;10:22221.

Axén I, Bergström C, Bronson M, Côté P, Nim GC, Goncalves G, Hebert JJ, Hertel JA, Innes S, Larsen OK, Meyer AL, Perle SM, O’Neill S, Weber 2nd KA, Young K, Leboeuf-Yde C. Misinformation, chiropractic and the COVID-19 pandemic. Chiropr Man Therap, 2020;28(1):65.

Rejc E, Smith AC, Weber KA, Ugiliweneza B, Bert RJ, Negahdar MJ, Boakye M, Harkema SJ, Angeli CA. Spinal cord imaging markers and recovery of volitional leg movement with spinal cord epidural stimulation in individuals with clinically motor complete spinal cord injury. Front Syst Neurosci, 2020; 14:77.

Paliwal M, Weber II KA, Hopkins B, Cantrell D, Hoggarth M, Elliott J, Dahdaleh NS, Mackey S, Parrish TB, Dhaher Y, Smith ZA. Magnetization Transfer Ratio and Morphometrics Of the Spinal Cord Associates with Surgical Recovery in Patients with Degenerative Cervical Myelopathy. World Neurosurgery, 2020;144:e939-e947.

Shover CL, Vest NA, Chen D, Stueber A, Falasinnu TO, Hah JM, Kim J, Mackey I, Weber II KA, Ziadni M, Humphreys K. Association of State Policies Allowing Medical Cannabis for Opioid Use Disorder with Dispensary Marketing for This Indication. JAMA Netw Open, 2020;3(7):e2010001.

Elliott JM, Smith AC, Hoggarth MA, Albin SR, Weber KA II, Haager M, Fundaun J, Wasielewski M, Courtney DM, Parrish TB. Muscle Fat Infiltration following Whiplash: A Computed Tomography and Magnetic Resonance Imaging Comparison. PLoS ONE, 2020;15(6):e0234061.

Weber II KA, Chen Y, Paliwal M, Law CS, Hopkins BS, Mackey S, Dhaher Y, Parrish TB, Smith ZA. Assessing the Spatial Distribution of Cervical Spinal Cord Activity during Tactile Stimulation of the Upper Extremity in Humans with Functional Magnetic Resonance Imaging. NeuroImage, 2020; 217:116905.

Franettovich Smith MM, Collins NJ, Mellor R, Grimaldi A, Elliott J, Hoggarth M, Weber K, Vicenzino B. Foot Exercise Plus Education Versus Wait and See for the Treatment of Plantar Heel Pain (FEET Trial): A Protocol for a Feasibility study. Journal of Foot and Ankle Research, 2020;13(1):20.

Smith ZA, Weber II KA, Paliwal M, Hopkins B, Barry A, Cantrell D, Ganju A, Koski TR, Parrish TB, Dhaher Y. MRI atlas-based volumetric mapping of the cervical cord gray matter in cervical canal stenosis. World Neurosurgery, 2020;13:e497-e504.

O’Dell DR, Weber KA, Berliner JC, Connor JR, Cummins DP, Heller KA, Hubert JS, Kates MJ, Mendoza KR, Smith AC. Midsagittal tissue bridges are associated with walking ability in incomplete spinal cord injury: a magnetic resonance imaging case series. Journal of Spinal Cord Medicine. 2020;42(2):268-271.

Weber KA II, Wager TD, Elliott JM, Mackey S, Liu WC, Sparks CL. Evidence for Decreased Neurologic Pain Signature Activation Following Thoracic Spine Manipulation in Healthy Volunteers and Neck Pain Participants. NeuroImage: Clinical, 2019;24:102042.

Hopkins B, Weber II K, Kesavabhotla K, Paliwal M, Smith ZA. Machine Learning for the Prediction of Cervical Spondylotic Myelopathy: A Post Hoc Pilot Study of 28 Participants. World Neurosurgery, 2019;127:e436-e442.

Weber II KA, Smith AC, Wasielewski M, Eghtesad K, Upadhyayula, PA, Wintermark M, Hastie TJ, Parrish TB, Mackey S, Elliott JM. Deep Learning Convolutional Neural Networks for the Automatic Quantification of Muscle Fat Infiltration Following Whiplash Injury. Scientific Reports, 2019;9(1):7973.

Cummins DP, Connor JR, Heller KA, Hubert JS, Kates MJ, Wisniewski KR, Berliner JC, O’Dell DR, Elliott JM, Weber II KA, Smith AC. Establishing the inter-rater reliability of spinal cord damage manual measurement using magnetic resonance imaging. Spinal Cord Series and Cases, 2019;5:20.

Crawford RJ, Fortin M, Weber II KA, Smith A, Elliott JM. Are Magnetic Resonance Imaging Technologies Crucial to Our Understanding of Spinal Conditions? Journal of Orthopaedic & Sports Physical Therapy 2019;49(5):320-329.

Martucci KT, Weber II KA, Mackey S. Altered Cervical Spinal Cord Resting State Activity in Fibromyalgia. Arthritis & Rheumatology 2019;71(3):441-450.

Islam H, Law CSW, Weber II KA, Mackey SC, Glover GH. Dynamic per slice Shimming for Simultaneous Brain and Spinal cord fMRI. Magnetic Resonance in Medicine 2019: 81:825-838.

Hopkins B, Weber II KA, Cloney MB, Paliwal M, Parrish TB, Smith ZA. Tract-Specific Volume Loss on 3T MRI in Patients with Cervical Spondylotic Myelopathy. Spine 2018: 43(20):E1204-E1209.

Suleiman L, Weber II K, Rosenthal BD, Savage JW, Hsu WK, Patel AA, Parrish TB. High-Resolution Magnetization Transfer MRI in Patients with Cervical Spondylotic Myelopathy. Journal of Clinical Neuroscience 2018;51:57-61.

Smith AC, Weber II KA, O’Dell DR, Parrish TB, Wasielewski M, Elliott JM. Lateral corticospinal tract damage correlates with motor output in incomplete spinal cord injury. Archives of Physical Medicine and Rehabilitation 2018;99:660-666.

Cloney MB, Smith ZA, Weber II KA, Parrish TB. Quantitative Magnetization transfer MRI measurements of the anterior spinal cord region are associated with clinical outcomes in cervical spondylotic myelopathy. Spine 2018;43:675-680.

Weber II KA, Sentis AI, Bernadel-Huey ON, Chen Y, Wang X, Parrish TB, Mackey S. Thermal Stimulation Alters Cervical Spinal Cord Functional Connectivity in Humans. Neuroscience 2018;369:40-50.

Smith AC, Weber II KA, Parrish TB, Hornby TG, Tysseling VM, McPherson JG, Wasielewski M, Elliott JM. Ambulatory function in motor incomplete spinal cord injury: A magnetic resonance imaging study of spinal cord edema and lower extremity muscle morphometry. Spinal Cord 2017;55:672-678.

Elliott JM, Owen M, Bishop MD, Sparks C, Tsao H, Walton DM, Weber 2nd KA, Wideman T. Measuring Pain for Patients Seeking Physical Therapy: Can Functional Magnetic Resonance Imaging (fMRI) Help? Physical Therapy 2017;97:145-155.

Weber II KA, Chen Y, Wang X, Kahnt T, Parrish TB. Functional Magnetic Resonance Imaging of the Spinal Cord During Thermal Stimulation Across Consecutive Runs. NeuroImage 2016;143:267-279.

Elliott JM, Dayanidhi S, Hazle C, Hoggarth MA, McPherson J, Sparks C, Weber 2nd KA. Advancements in Imaging Technology: Do They (or Will They) Equate to Advancements in Our Knowledge of Recovery in Whiplash? Journal of Orthopaedic & Sports Physical Therapy 2016;46:862-73.

Weber II KA, Chen Y, Wang X, Kahnt T, Parrish TB. Lateralization of Cervical Spinal Cord Activity During an Isometric Upper Extremity Motor Task. NeuroImage 2016;125:233-243.

Wang X, Casadio M, Weber II KA, Parrish T, Mussa-Ivaldi F. White Matter Microstructure Changes Induced by Motor Skill Learning Utilizing a Body Machine Interface. NeuroImage 2013;88C:32-40.

Dishman JD, Weber II KA, Corbin RL, Burke JR. Understanding Inhibitory Mechanisms of Lumbar Spinal Manipulation Using H-reflex and F-wave Responses: A Methodological Approach. J Neurosci Methods 2012;210:169-177.

Madhavan S, Weber 2nd KA, Stinear JW. Non-invasive Brain Stimulation Enhances Fine Motor Control of the Hemiparetic Ankle: Implications for Rehabilitation. Exp Brain Res 2011;209:9-17.

Weber II KA, He X. Chiropractic Students and Research: Assessing the Research Culture at a North American Chiropractic College. J Chiropr Educ 2010;24:35-45.